Chronic sleep deprivation

Chronic sleep deprivation is a persistent habit of not getting enough sleep, which can significantly impact physical and mental health over time. Studies have found that chronic lack of sleep disrupts neurobehavioral functions and impairs cognitive performance, similar to the effects of total sleep deprivation but with cumulative damage. It also exacerbates microglial reactivity and increases amyloid-beta deposition in the brain, potentially contributing to neurodegenerative diseases. Additionally, chronic sleep deprivation can lead to disruptions in appetite regulation, often resulting in increased hunger and a higher risk of overeating.

Chronic sleep deprivation is closely linked to several health issues, including cognitive deficits and neurodegenerative conditions like Alzheimer's disease. It also plays a role in the development of chronic diseases such as obesity and diabetes by affecting metabolic processes and appetite control. In teenagers, this habit can be particularly detrimental, impacting their academic performance and emotional well-being.

While these findings are robust, more research is needed to fully understand the long-term effects of chronic sleep deprivation on different populations.

Sources

• The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. (PMID:12683469)
• Sleep Deprivation, Sleep Disorders, and Chronic Disease. (PMID:37651644)
• Melatonin attenuates chronic sleep deprivation-induced cognitive deficits and HDAC3-Bmal1/clock interruption. (PMID:37721401)
• Sleep Deprivation and Central Appetite Regulation. (PMID:36558355)
• Chronic sleep deprivation in teenagers: Practical ways to help. (PMID:34144910)
• Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice. (PMID:37099634)

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