Creatine monohydrate
Creatine monohydrate is a popular dietary supplement that has gained attention for its potential benefits in muscle function and cognitive health. Studies have explored its effects on various aspects of physical and mental well-being, including muscle mass, bone density, and cognitive decline. In Alzheimer's disease, preliminary research indicates that creatine monohydrate may improve brain creatine levels and cognitive performance, though more studies are needed to confirm these findings. For general health, evidence suggests that creatine supplementation can help protect against cognitive decline, support muscle mass, and enhance bone density, particularly in older adults.
The strongest connections supported by cohort studies include the supplement's role in protecting against cognitive decline, helping with muscle mass, and improving bone density. Additionally, there is some evidence that creatine monohydrate may also aid in managing depression and improving sleep quality. However, while these findings are promising, the evidence is currently moderate, and more robust research is needed to fully understand the extent of these benefits.
Sources
- Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. (PMID:40395689)
- Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (PMID:33557850)
- Effects of Creatine Supplementation on Brain Function and Health. (PMID:35267907)
- Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults? (PMID:39509039)
- Effects of Creatine Monohydrate on Endurance Performance in a Trained Population: A Systematic Review and Meta-analysis. (PMID:36877404)
- The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. (PMID:39070254)
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Connections
Creatine monohydrate helps
- Muscular StrengthPositive Condition
- Muscle HypertrophyPositive Condition
- Sprint PerformancePositive Condition
- Cognitive PerformancePositive Condition
- Sleep DeprivationNegative Condition
- DepressionMental Health
- Parkinsons DiseaseDisease
- Traumatic Brain InjuryNegative Condition
- VO2 maxBiomarker
- Muscle MassPositive Condition
- Sleep QualityPositive Condition
- Bone DensityPositive Condition
Creatine monohydrate synergizes with
Creatine monohydrate protects against
Creatine monohydrate is a form of
Creatine monohydrate regulates
Creatine monohydrate is contained in
Creatine monohydrate is helped by
Creatine monohydrate harms
Creatine monohydrate antagonizes
Sources
- International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine (2017) clinical-guideline
- Creatine supplementation and cognitive performance: a systematic review (2018) review
- Creatine supplementation with specific view to exercise/sports performance and aging muscle (2017) review
- Creatine for the treatment of depression: a systematic review (2021) review
- Effect of Creatine Monohydrate on Clinical Progression in Patients with Parkinson Disease (NET-PD LS-1) (2015) review
- Effects of acute creatine supplementation on brain function and cognition during sleep deprivation (2024) review
- USDA FoodData Central (2024) dataset
- Examine.com Creatine evidence summary (2024) review
- Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. (2025) pubmed
- Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (2021) pubmed
- Effects of Creatine Supplementation on Brain Function and Health. (2022) pubmed
- Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults? (2024) pubmed
- Effects of Creatine Monohydrate on Endurance Performance in a Trained Population: A Systematic Review and Meta-analysis. (2023) pubmed
- The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. (2024) pubmed
- Creatine Supplementation Beyond Athletics: Benefits of Different Types of Creatine for Women, Vegans, and Clinical Populations-A Narrative Review. (2024) pubmed
- Creatine supplementation. (2013) pubmed
- Creatine monohydrate supplementation for older adults and clinical populations. (2025) pubmed
- Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials. (2023) pubmed