hs-CRP

High-sensitivity C-reactive protein (hs-CRP) is a biomarker that measures low levels of inflammation in the body, which can be an indicator of various health conditions including cardiovascular disease and metabolic disorders. Studies have found that elevated hs-CRP levels are associated with increased risks of stroke, cardiovascular mortality, and cancer. Additionally, the ratio of hs-CRP to HDL cholesterol (HDL-C) has been linked to sarcopenia and chronic obstructive pulmonary disease (COPD). In patients with hypothyroidism, co-supplementation with zinc, vitamin A, and magnesium can reduce hs-CRP levels, potentially improving thyroid function and reducing oxidative stress. The role of hs-CRP in post-myocardial infarction (post-MI) sequelae highlights its importance in understanding the mechanisms and clinical significance of inflammation following heart attacks.

The evidence for these associations is primarily derived from meta-analyses and cross-sectional studies, which provide strong observational data but do not establish causality. Further randomized controlled trials are needed to confirm these findings.

Sources

• Hs-CRP in stroke: A meta-analysis. (PMID:26633855)
• Hs-CRP/HDL-C ratio as a predictive inflammatory-lipid marker for sarcopenia: evidence from NHANES 2015-2018. (PMID:40672942)
• Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis. (PMID:28327451)
• Association of hs-CRP/HDL, AIP and NHHR with chronic obstructive pulmonary disease: a cross-sectional NHANES study. (PMID:40538265)
• Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism. (PMID:33409923)
• Role of hs-CRP in Post-MI Sequelae: Insights into Mechanisms and Clinical Significance. (PMID:40663124)

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