Magnesium glycinate
Magnesium glycinate is a form of magnesium supplement that is often chosen for its high bioavailability and gentle effects on the digestive system. Studies have found that magnesium glycinate is absorbed more efficiently than other forms, such as magnesium oxide, particularly in individuals with ileal resection. Chronic administration has been shown to support intestinal motility and maintain body weight in rats, without adverse effects on food or water intake. However, combined supplementation with vitamin D did not significantly impact bone turnover markers or glycemic control in humans.
Magnesium glycinate helps build muscle mass and supports bone density, both of which are important for overall health and physical performance. It also has anti-inflammatory properties and may protect against cardiovascular disease by improving blood pressure. These benefits are supported by randomized controlled trials, making them more reliable than observational findings.
While the evidence is promising, it's important to note that some studies have limitations, and further research is needed to fully understand the long-term effects of magnesium glycinate supplementation.
Sources
- Dose-Dependent Absorption Profile of Different Magnesium Compounds. (PMID:30761462)
- Effect of chronic administration of magnesium supplement (magnesium glycinate) on male albino wistar rats' intestinal (Ileum) motility, body weight changes, food and water intake. (PMID:37636381)
- Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. (PMID:7815675)
- Combined vitamin D and magnesium supplementation does not influence markers of bone turnover or glycemic control: A randomized controlled clinical trial. (PMID:36640582)
- The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial. (PMID:35576873)
- Magnesium yields opposite effects on the nuclear and cytosolic cascades of apoptosis in different rat brain regions. (PMID:36196701)
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Sources
- USDA FoodData Central (2024) dataset
- Magnesium - Fact Sheet for Health Professionals (2024) nih
- The Effect of Magnesium Supplementation on Primary Insomnia in Elderly: a double-blind placebo-controlled clinical trial; subsequent reviews (2021) review
- The Effects of Magnesium Supplementation on Subjective Anxiety and Stress - A Systematic Review (2017) review
- Magnesium status and stress: the vicious circle concept revisited (2020) review
- Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials (2016) review
- Dietary magnesium intake and risk of incident type 2 diabetes: meta-analysis of prospective cohort studies (2016) review
- American Headache Society / American Academy of Neurology guideline on migraine prophylaxis (2012) clinical-guideline
- Magnesium, vitamin D status and mortality (2018) review
- Magnesium in man: implications for health and disease (2015) review
- Dose-Dependent Absorption Profile of Different Magnesium Compounds. (2019) pubmed
- Effect of chronic administration of magnesium supplement (magnesium glycinate) on male albino wistar rats' intestinal (Ileum) motility, body weight changes, food and water intake. (2023) pubmed
- Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. (1994) pubmed
- Combined vitamin D and magnesium supplementation does not influence markers of bone turnover or glycemic control: A randomized controlled clinical trial. (2023) pubmed
- The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial. (2022) pubmed
- Magnesium yields opposite effects on the nuclear and cytosolic cascades of apoptosis in different rat brain regions. (2022) pubmed
- Magnesium - The Silent Partner or the Next Vitamin D? Shifting Paradigm in Mineral Metabolism in Health and Disease. (2026) pubmed
- A Challenging Case of Hypercalcemia Caused by a Novel Homozygous Variant Missense Mutation in the CYP24A1 Gene. (2026) pubmed