Oxidative stress

Oxidative stress is a condition where there's an imbalance between the production of free radicals and the body’s ability to counteract their harmful effects through neutralization by antioxidants, which can lead to cellular damage and various diseases.

Several studies highlight the role of oxidative stress in different health conditions. In cancer, oxidative stress contributes to DNA damage, inflammation, and cell proliferation, promoting tumor growth. In Alzheimer's disease, it damages neurons and impairs cognitive function. Intervertebral disc degeneration is also linked to oxidative stress, which accelerates the breakdown of disc tissues. Additionally, oxidative stress can induce angiogenesis, the formation of new blood vessels, which is crucial in both physiological processes and pathological conditions like tumor growth.

Oxidative stress connects closely with cancer development, neurodegenerative diseases like Alzheimer's, and musculoskeletal disorders such as intervertebral disc degeneration.

While these findings are robust, more research is needed to fully understand the mechanisms and therapeutic implications.

Sources

• Oxidative stress: a concept in redox biology and medicine. (PMID:25588755)
• Oxidative stress and its role in cancer. (PMID:33723127)
• Oxidative stress and antioxidant strategies in dermatology. (PMID:26020527)
• Oxidative stress in Alzheimer's disease. (PMID:24664866)
• The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications. (PMID:38734147)
• Oxidative stress-induced angiogenesis. (PMID:30837109)

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